Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Physiology and pathophysiology of the retina

Neuroprotective therapy: Exosomes preserve photoreceptors during retinal degeneration

Retina degeneration is a health condition affecting posterior lining of the eye which is less accessible and deserves greater attention in terms of prevention and treatment. One of the most common types of retinal diseases is Retinitis pigmentosa (RP) resulting in visual impairment and irreversible blindness. Despite many therapeutic strategies have provided promising results and many of those have entered clinical trials but there is still no absolute cure for RP. Artikel lesen

Müller Glia cells: A Promising Target for Therapeutic Regeneration and Neuroprotection of degenerated retina

Müller glial cells (MGCs) are a unique architectural cell type that lengthen the entire thickness of the retinal tissue. As they are endowed with different ion channels, ligand receptors, transmembraneous transporter molecules and enzymes, these cells are involved in various retinal functions such as process contacts to neighboring neurons, maintaining retinal homeostasis and supplying neural protection. Artikel lesen

Mouse Retinal Ganglion Cells Visual Characterization toolbox

The retina has many parallel information processing channels. As a result, the ganglion cells which pass information to the brain consist of dozens of different types. All the ganglion cells of a single type constitute a visual information channel; and each of these channels carries a different message about the visual world to the brain (see Figure). Ensuring that bionic retinal implants fully exploit this diversity of information channels has been a long-term goal of bionic vision research. Artikel lesen

Selective On/OFF stimulation of the retina in visual protheses

In our investigations of retinal responses to electrical stimulation, we have learned of a handful of strategies by which it may be possible for a single electrode to selectively or at least preferentially stimulate chosen subtypes of the retinal ganglion cell population. Artikel lesen

In vitro retinal chip setup

The in vitro chip setup project is concerned with using the Alpha-AMS retinal implant chip in vitro to support clinical translation of basic research findings from our research group. The chip setup is equipped with a suite of components including: an electrophysiology setup (tungsten single electrode and patch clamp recording) and a customized optical path for both visual stimulation of the chip and visualization of the chip and retinal cells. Artikel lesen

Physiology and pathophysiology of retinal circuits

The retina is a part of the CNS, architecturally simple yet functionally complex, where the visual information is captured by rod and cone photoreceptors in the outer retina and then integrated and processed by interneurons e.g. amacrine, bipolar, horizontal cells, and transmitted to the brain by retinal ganglion cells (RGCs) in the inner retina. Worldwide over 8 million people suffer from retinitis pigmentosa and macular degeneration, which lead to loss of photoreceptor function and blindness. We aim to restore the visual function in these patients by advancing the electronic retinal implant. Artikel lesen
last update: 05.11.2020, 13:31 Uhr
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Paul-Flechsig-Institut für Hirnforschung