Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

non protein coding RNA

Are selective RNA patterns suitable biomarkers for neurodegenerative diseases?

In contrast to other organs human brain is characterized by a huge heterogeneity and diversity of RNA. Current studies suggest altered RNA metabolism being substantially involved in progression of Alzheimer’s disease (AD) already at early stages. It seems promising to consider usage of specific and disease associated RNA patterns to detect or even monitor progression of AD. Artikel lesen
 
 

miRNA in Glioblastoma multiforme

The most frequent malignant braintumor “Glioblastoma multiforme” (GBM) is characterized by an extraordinary histomorphological and molecular diversity. While it is well known that tumorcells cause massive changes in their microenvironment, mainly in the extracellular matrix (ECM) and the local physiological cells, less is known about the reverse effect of the ECM on tumorcells and the malignant potential of bystander cells as part in creating the intratumoral heterogeneity. Artikel lesen
 
 

Functional characterization of long non-coding RNAs in Alzheimer's disease

The project will establish the specific pathogenetic role of long ncRNAs (lncRNAs) in Alzheimer´s di-sease (AD) and specify the link to neurodegeneration. To this end, we will identify and characterize functionally relevant lncRNA-target interactions of lncRNAs, previously identified in a genome-wide approach to be differentially expressed between AD and human control brain. Artikel lesen
 
 
 
last update: 04.06.2018, 14:35 Uhr
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Paul-Flechsig-Institut für Hirnforschung