Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Are selective RNA patterns suitable biomarkers for neurodegenerative diseases?

In contrast to other organs human brain is characterized by a huge heterogeneity and diversity of RNA. Current studies suggest altered RNA metabolism being substantially involved in progression of Alzheimer’s disease (AD) already at early stages. It seems promising to consider usage of specific and disease associated RNA patterns to detect or even monitor progression of AD.

Consequently, the project is focused on the relation between RNA diversity and neurodegeneration to develop new tools for RNA-based diagnostic approaches. Both coding and non-coding RNAs (ncRNA) exert critical impact on the regulation of neuronal differentiation and are therefore involved in the study. RNAs containing coding and extremely long non-coding parts are of specific interest. Selected data are obtained using Surface Plasmon Resonance approach (SPR).



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last update: 04.06.2018, 14:35 Uhr
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Paul-Flechsig-Institut für Hirnforschung