Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Modelling Alzheimer-like phosphorylation of tau in hibernation

Alzheimer´s disease is a disorder of higher age, characterised by cognitive decline due to a progressive degeneration of neurons beginning in the synaptic compartment. This neurodegenerative process is characterized by the formation of extracellular Aß-plaques and intracellular ‘paired helical filaments' made up by a hyperphosphorylated form of the microtubule-associated protein tau.

Recently, we described the reversible formation of hyperphosphorylated tau under physiological conditions of hibernation associated with synaptic regression and cognitive dysfunction. Hibernation, thus, represents a unique model to study under physiological in vivo conditions the molecular regulation and cell biological significance of tau-hyperphosphorylation and its association with regressive synaptic changes in the neuronal fine structure and cognitive function. The present project aims at the analysis of the regulation and pathogenetic role of tau-hyperphosphorylation and its potential links to synaptic regression and cognitive function. This goal will be achieved by a multidisciplinary approach combining enzyme- and protein-biochemical techniques with proteomic, immunohistochemical, ultrastructural and behavioural analyses.

Workgroup


 
last update: 20.01.2017, 15:23 Uhr
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Paul-Flechsig-Institut für Hirnforschung