Extracellular Matrix

The influence of perineuronal nets on the aggregation and spreading of Tau protein in Alzheimer's disease

Neurodegenerative diseases, including Alzheimer's disease (AD) are characterized by a distinct pattern of spatial and temporal distribution of histopathological markers. AD is pathologically characterized by the deposition of β-amyloid plaques as well as neurofibrillary tangles, which consist of non-physiological, hyperphosphorylated Tau. Artikel lesen

The role of extracellular matrix in dystonia and dyskinesia

Dystonia is a common movement disorder, characterized by involuntary and extended muscle contraction resulting in repetitive movements and abnormal postures. Dystonic movements are typically patterned and twisting, and may be tremulous. Dystonia is often initiated or worsened by voluntary action and associated with overflow muscle activation. Artikel lesen

Extracellular matrix of perineuronal nets in the auditory system: from structure to function

The central nervous system (CNS) is mainly composed of two types of cells, neurons and glia cells, which form most of the CNS volume. Still, about 20% of CNS volume is generated by extracellular matrix (ECM) which is composed of specific macromolecules that fill the extracellular space and remarkably contribute to the cellular and structural organization of the CNS. Perineuronal nets (PNs), in this regard are classified as a specialized composition of ECM molecules which surrounds the soma, dendrites and the axon initial segment of particular neurons in the CNS. Artikel lesen