Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Alterations of the neurovascular unit after ischaemic stroke in rats and mice

Comprehensive data on altered components of the functionally important “neurovascular unit” (NVU) after ischaemic stroke are a prerequisite for possible rational targeting of therapeutic approaches. This study was started in 2010 and is focused on pathological alterations after experimentally induced cerebral ischaemia in rats and mice.

Based on numerous histological markers we analyse main components of NVU: basal membranes and endothelia of vessels, astrocytes, microglia, oligodendrocytes, neurons and extracellular matrix. Considering the hypothesis of an age-dependency of such alterations, we also apply differently aged, 3- and 12-month-old mice. Moreover, the study includes the comparison of ischaemia-related changes between wild-type mice and co-morbid, transgenic mice with age-dependent Alzheimer-like lesions.

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A: Glial reaction 7 days after experimentally induced ischaemia in the forebrain of a rat. Immunofluorescence  labelling of microglia/macrophages  in the striatum and in the neocortex.

B: One day after experimentally induced stroke, the ischaemic region is devoid of aquaporin 4-staining (red), while the potato lectin (STL) detects apparently unaltered endothelial cells (green).



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last update: 12.01.2017, 13:13 Uhr
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Paul-Flechsig-Institut für Hirnforschung