Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Cellcycle and Aneuploidy

Examination of chromosomal aberrations in hippocampal formation of AD brain

Alzheimer’s disease (AD) is characterized by a massive loss of neurons in several brain regions. Recent results suggest that altered neuronal DNA content is at least partially causative for neuronal cell death. So in AD cortical pyramidal cells display aneuploidy or polyploidy indicating altered or disturbed regulation of DNA replication. Artikel lesen

Innovative treatment of Alzheimer's disease and related disorders - Concept for a somatic gene therapy

Alzheimer's disease (AD) and stroke giving rise to vascular dementia (VD) are most prominent causes for mental impairment in the adult and elderly. AD and stroke share a cell death pathway that is activated by unscheduled neuronal cell cycle re-entry and subsequent partial replication of DNA. Artikel lesen

Single cell genomics of the brain in healthy controls and disease

We recently described chromosomal copy number variation (CHROM-CNV) due to loss or gain of whole chromosomes or fragments thereof both in the normal and diseased adult human brain, namely Alzheimer´s disease (AD). In sporadic AD, we observed accelerated cell death for neurons with CHROM-CNV. This indicates that maintenance of neurons with CHROM-CNV in the adult CNS might be a widespread phenomenon. While during development, neurons with CHROM-CNV might be cleared through apoptosis, certain neurons still may escape this selection and persist into adulthood. Artikel lesen

Mosaic neuronal aneuploidy in Alzheimer's disease - a potential genetic basis for selective neuronal vulnerability in neurodegeneration

Understanding the molecular principles of complex human diseases of the nervous system remains a basic challange to neuroscience. Structural variation in the human genome is likely to be one important mechanism for neuronal diversity and brain diseases. Artikel lesen
last update: 28.07.2020, 15:28 Uhr
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Paul-Flechsig-Institut für Hirnforschung