Paul-Flechsig-Institut für Hirnforschung
 Universitätsmedizin Leipzig

Examination of chromosomal aberrations in hippocampal formation of AD brain

Alzheimer’s disease (AD) is characterized by a massive loss of neurons in several brain regions. Recent results suggest that altered neuronal DNA content is at least partially causative for neuronal cell death. So in AD cortical pyramidal cells display aneuploidy or polyploidy indicating altered or disturbed regulation of DNA replication.

Though intact hippocampus formation (HC) is important for declarative memory and HC function is early affected during progression of AD, extent and distribution of chromosomal alterations are scarcely studied.
Thus the aim of the project is to analyze numeric chromosomal aberration in hippocampal neurons of AD brains. To this purpose single cell isolation will be linked with modern sequencing strategies to obtain new insights into the pathomechanism of neuronal cell death in AD.

Workgroup


Partners


Funding

 
last update: 28.07.2020, 15:28 Uhr
Zurück zum Seitenanfang springen
Zurück zum Seitenanfang springen
Paul-Flechsig-Institut für Hirnforschung